02.02.2010

A Peek In the Toolbox

Key Elements - Over the course of previous decades, worldwide research has continued to be focused on increasingly sophisticated novel methods for the development of chiral building blocks. These compounds are now a key element in the synthesis routes selection for the manufacture of active pharmaceutical ingredients. In principle, three routes to these chiral building blocks can be described (fig. 1): more29.01.2010

Chirals: The Real Deal

Getting Easier - The number of drug candidates containing a stereogenic center continues to increase, necessitating selective syntheses of aspecific isomer. As the number of methods increases, this is becoming less onerous. The ‘Problem' more